General Information

    • DRAMP ID

    • DRAMP00924

    • Peptide Name

    • Cyclopeptide E (Plant defensin)

    • Source

    • Annona cherimola (Custard apple) (Cherimoya)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • PGLGFY

    • Sequence Length

    • 6

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Anti-cancer, Cytotoxic

    • Target Organism

    • Human nasopharyngeal carcinoma (IC50=17 nM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00924 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00924.

Physicochemical Information

    • Formula

    • C33H44N6O8

    • Absent Amino Acids

    • ACDEHIKMNQRSTVW

    • Common Amino Acids

    • G

    • Mass

    • 652.75

    • PI

    • 5.95

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • 0

    • Boman Index

    • 9.64

    • Hydrophobicity

    • 0.483

    • Aliphatic Index

    • 65

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 298

    • Polar Residues

    • 3

DRAMP00924

Comments Information

    • Function

    • Probably participates in a plant defense mechanism. Has cytotoxic activity against human nasopharyngeal carcinoma.

    • PTM

    • This is a cyclic peptide.

Literature Information

  • ·Literature 1

    • Title

    • Two cyclopeptides from the seeds of Annona cherimola.

    • Reference

    • Phytochemistry. 2005 Oct;66(19):2376-2380.

    • Author

    • Wélé A, Zhang Y, Brouard JP, Pousset JL, Bodo B.