General Information
-
DRAMP ID
- DRAMP00927
-
Peptide Name
- Cyclotide vico-A (Plant defensin)
-
Source
- Viola cotyledon (Violeta)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GSIPCAESCVYIPCFTGIAGCSCKNKVCYYN
-
Sequence Length
- 31
-
UniProt Entry
- P84635
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00927.
Physicochemical Information
-
Formula
- C142H217N35O43S6
Absent Amino Acids
- DHLMQRW
Common Amino Acids
- C
Mass
- 3294.85
PI
- 7.76
Basic Residues
- 2
Acidic Residues
- 1
Hydrophobic Residues
- 8
Net Charge
- +1
-
Boman Index
- -4.44
Hydrophobicity
- 0.439
Aliphatic Index
- 62.9
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 4845
Absorbance 280nm
- 161.5
Polar Residues
- 18
DRAMP00927
![DRAMP00927 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP00927.1.png)
Comments Information
Function
- Probably participates in a plant defense mechanism.
PTM
- Problely contains three disulfide bonds 5-21; 9-23; 14-28. This is a cyclic peptide (cross-link at G1-N31).
Literature Information
- ·Literature 1
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Title
- Expression of Viola cyclotides by liquid chromatography-mass spectrometry and tandem mass spectrometry sequencing of intercysteine loops after introduction of charges and cleavage sites by aminoethylation.
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Pubmed ID
- 12782038
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Reference
- Anal Biochem. 2003 Jul 1;318(1):107-117.
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Author
- Göransson U, Broussalis AM, Claeson P.