General Information

    • DRAMP ID

    • DRAMP00930

    • Peptide Name

    • Antimicrobial peptide 2 (Cn-AMP2; Plant defensin)

    • Source

    • Cocos nucifera (Coconut palm)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • TESYFVFSVGM

    • Sequence Length

    • 11

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.19111587] Gram-positive bacteria: Bacillus subtilis (MIC=150 μg/ml), Staphylococcus aureus (MIC=170 μg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=170 μg/ml), Pseudomonas aeruginosa (MIC=169 μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00930 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C59H83N11O18S

    • Absent Amino Acids

    • ACDHIKLNPQRW

    • Common Amino Acids

    • FSV

    • Mass

    • 1266.43

    • PI

    • 4

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • -1

    • Boman Index

    • 1.01

    • Hydrophobicity

    • 0.764

    • Aliphatic Index

    • 52.73

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 149

    • Polar Residues

    • 5

DRAMP00930

Comments Information

    • Function

    • Antibacterial activity against Gram-negative and Gram-positive bacteria.

    • Tissue specificity

    • Found in the liquid endosperm contained in green fruit of coconut palms, also known as coconut water (at protein level).

    • Subunit structure

    • Monomer.

Literature Information

  • ·Literature 1

    • Title

    • Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water.

    • Reference

    • Peptides. 2009 Apr;30(4):633-637.

    • Author

    • Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL.