General Information

    • DRAMP ID

    • DRAMP00937

    • Peptide Name

    • Tu-AMP1 (Plant defensin)

    • Source

    • Tulipa gesneriana L.

    • Family

    • Belongs to the thionin family

    • Gene

    • Not found

    • Sequence

    • KSCCRNTVARNCYNVCRIPGTPRPVCAATCDCKLITGTKCPPGYEK

    • Sequence Length

    • 46

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Bacteria: Erwinia carotovora (IC50=11 µg/ml), Agrobacterium radiobacter (IC50=15 µg/ml), Agrobacterium rhizogenes (IC50=20 µg/ml);
      • Gram-positive bacteria: Clavibacter michiganensis (IC50=14 µg/ml), Curtobacterium flaccumfaciens (IC50=13 µg/ml).
      • Fungi: Fusarium oxysporum (IC50=2 µg/ml), Geotrichum candidum (IC50=2 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Chitin-binding

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00937 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00937.

Physicochemical Information

    • Formula

    • C207H345N65O62S8

    • Absent Amino Acids

    • FHMQW

    • Common Amino Acids

    • C

    • Mass

    • 4992.89

    • PI

    • 9.08

    • Basic Residues

    • 8

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +6

    • Boman Index

    • -88.49

    • Hydrophobicity

    • -0.357

    • Aliphatic Index

    • 50.87

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 3480

    • Absorbance 280nm

    • 77.33

    • Polar Residues

    • 22

DRAMP00937

DRAMP00937 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Purification, characterization, and sequencing of novel antimicrobial peptides, Tu-AMP 1 and Tu-AMP 2, from bulbs of tulip (Tulipa gesneriana L.).

    • Reference

    • Biosci Biotechnol Biochem. 2004 Mar;68(3):571-577.

    • Author

    • Fujimura M, Ideguchi M, Minami Y, Watanabe K, Tadera K.