General Information
-
DRAMP ID
- DRAMP00995
-
Peptide Name
- IB-AMP2 (IBAMP2; Basic peptide AMP2; Plants)
-
Source
- Impatiens balsamina (Balsam)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- QYGRRCCNWGPGRRYCKRWC
-
Sequence Length
- 20
-
UniProt Entry
- O24006
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
-
Target Organism
-
- Fungi: Alternaria longipes (IC50=12 µg/ml), Botrytis cinerea (IC50=25 µg/ml), Cladosporium sphaerospermum (IC50=6 µg/ml), Fusarium culmorum (IC50=6 µg/ml), Penicillium digitatum (IC50=6 µg/ml), Trichoderma viride (IC50=12 µg/ml), Verticillium alboatrum (IC50=12 µg/ml).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP00995.
Physicochemical Information
-
Formula
- C108H162N40O25S4
Absent Amino Acids
- ADEFHILMSTV
Common Amino Acids
- R
Mass
- 2548.97
PI
- 9.93
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 2
Net Charge
- +6
-
Boman Index
- -80.01
Hydrophobicity
- -1.53
Aliphatic Index
- 0
Half Life
-
- Mammalian:0.8 hour
- Yeast:10 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 14230
Absorbance 280nm
- 748.95
Polar Residues
- 10
DRAMP00995
Comments Information
Developmental stage
- Highly expressed in dry mature seed and by the stages 2-5 of developing seed.
PTM
- Contains two disulfide bonds C6-C16; C7-C20 and Pyrrolidone carboxylic acid at position 1 (Probable).
Literature Information
- ·Literature 1
-
Title
- A novel family of small cysteine-rich antimicrobial peptides from seed of Impatiens balsamina is derived from a single precursor protein.
-
Pubmed ID
- 9305910
-
Reference
- J Biol Chem. 1997 Sep 26;272(39):24480-24487.
-
Author
- Tailor RH, Acland DP, Attenborough S, Cammue BP, Evans IJ, Osborn RW, Ray JA, Rees SB, Broekaert WF.