General Information

    • DRAMP ID

    • DRAMP01000

    • Peptide Name

    • Ascalin (Plants)

    • Source

    • Allium cepa var. aggregatum (shallot)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • YQCGQGG

    • Sequence Length

    • 7

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal, Antiviral

    • Target Organism

    • Botrytis cinerea, HIV-1 reverse transcriptase (IC50=10 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01000 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01000.

Physicochemical Information

    • Formula

    • C28H41N9O11S

    • Absent Amino Acids

    • ADEFHIKLMNPRSTVW

    • Common Amino Acids

    • G

    • Mass

    • 711.75

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 0

    • Net Charge

    • 0

    • Boman Index

    • -7.12

    • Hydrophobicity

    • -1

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 248.33

    • Polar Residues

    • 5

DRAMP01000

Comments Information

    • Function

    • Has antifungal activity against Botrytis cinerea. Inhibits HIV-1 reverse transcriptase.

    • Miscellaneous

    • Inhibits HIV-1 reverse transcriptase with an IC50 of 10 µM.

Literature Information

  • ·Literature 1

    • Title

    • Ascalin, a new anti-fungal peptide with human immunodeficiency virus type 1 reverse transcriptase-inhibiting activity from shallot bulbs.

    • Reference

    • Peptides. 2002 Jun;23(6):1025-1029.

    • Author

    • Wang HX, Ng TB.