General Information

    • DRAMP ID

    • DRAMP01002

    • Peptide Name

    • Alpha-benincasin (Plants)

    • Source

    • Benincasa hispida

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RDWERREFERRQNELRREQEQRREELL

    • Sequence Length

    • 27

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Coprinus comatus, Pseudocercospora piricola.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01002 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01002.

Physicochemical Information

    • Formula

    • C155H253N59O50

    • Absent Amino Acids

    • ACGHIKMPSTVY

    • Common Amino Acids

    • R

    • Mass

    • 3743.08

    • PI

    • 6.46

    • Basic Residues

    • 9

    • Acidic Residues

    • 9

    • Hydrophobic Residues

    • 5

    • Net Charge

    • 0

    • Boman Index

    • -200.67

    • Hydrophobicity

    • -2.693

    • Aliphatic Index

    • 43.33

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 211.54

    • Polar Residues

    • 1

DRAMP01002

DRAMP01002 chydropathy plot

Comments Information

    • Function

    • Has weak antifungal activity toward C. comatus and P. piricola but not toward M. arachidicola. Inhibits cell-free translation in rabbit reticulocyte lysate system.

    • Miscellaneous

    • IC50 of 20 pM in rabbit reticulocyte.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of alpha- and beta-benincasins, arginine/glutamate-rich peptides with translation-inhibiting activity from wax gourd seeds.

    • Reference

    • Peptides. 2003 Jan;24(1):11-16.

    • Author

    • Ng TB, Parkash A, Tso WW.