General Information
-
DRAMP ID
- DRAMP01003
-
Peptide Name
- Gymnin (Plants)
-
Source
- Gymnocladus chinensis
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- KTCENLADDY
-
Sequence Length
- 10
-
UniProt Entry
- P84200
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal, Antiviral
-
Target Organism
-
- Fungi: Fusarium oxysporum (IC50=2 µM), Mycosphaerella arachidicola (IC50=10 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01003.
Physicochemical Information
-
Formula
- C48H74N12O20S
Absent Amino Acids
- FGHIMPQRSVW
Common Amino Acids
- D
Mass
- 1171.24
PI
- 4.03
Basic Residues
- 1
Acidic Residues
- 3
Hydrophobic Residues
- 2
Net Charge
- -2
-
Boman Index
- -31.14
Hydrophobicity
- -1.18
Aliphatic Index
- 49
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 165.56
Polar Residues
- 4
DRAMP01003
Comments Information
Function
- Exerts antifungal activity. Has weak mitogenic activity against murine splenocytes. Displays antiproliferative activity on a human hepatoma cell line and mouse leukemia cell lines. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase.
Literature Information
- ·Literature 1
-
Title
- Gymnin, a potent defensin-like antifungal peptide from the Yunnan bean (Gymnocladus chinensis Baill).
-
Pubmed ID
- 14499273
-
Reference
- Peptides. 2003 Jul;24(7):963-968.
-
Author
- Wong JH, Ng TB.