• DRAMP ID

    • DRAMP01003
    • Peptide Name

    • Gymnin (Plants)
    • Source

    • Gymnocladus chinensis
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • KTCENLADDY
    • Sequence Length

    • 10
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antifungal, Antiviral
    • Target Organism

      • Fungi: Fusarium oxysporum (IC50=2 µM), Mycosphaerella arachidicola (IC50=10 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01003 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01003.
    • Formula

    • C48H74N12O20S
    • Absent Amino Acids

    • FGHIMPQRSVW
    • Common Amino Acids

    • D
    • Mass

    • 1171.24
    • PI

    • 4.03
    • Basic Residues

    • 1
    • Acidic Residues

    • 3
    • Hydrophobic Residues

    • 2
    • Net Charge

    • -2
    • Boman Index

    • -31.14
    • Hydrophobicity

    • -1.18
    • Aliphatic Index

    • 49
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 165.56
    • Polar Residues

    • 4

DRAMP01003

    • Function

    • Exerts antifungal activity. Has weak mitogenic activity against murine splenocytes. Displays antiproliferative activity on a human hepatoma cell line and mouse leukemia cell lines. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase.
  • ·Literature 1
    • Title

    • Gymnin, a potent defensin-like antifungal peptide from the Yunnan bean (Gymnocladus chinensis Baill).
    • Reference

    • Peptides. 2003 Jul;24(7):963-968.
    • Author

    • Wong JH, Ng TB.