General Information

    • DRAMP ID

    • DRAMP01005

    • Peptide Name

    • Cicerarin (Plant defensin)

    • Source

    • Cicer arietinum (chickpea)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VKSTGRADDDLAVKTKYLPP

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal, Antiviral

    • Target Organism

      • Fungi: Botrytis cinerea (IC50=20.6 µM), Mycosphaerella arachidicola (IC50=15.3 µM), Pseudocercospora piricola (IC50=8.2 µM).
      • Virus: HIV-1 RT (IC50=87.5 µM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01005 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01005.

Physicochemical Information

    • Formula

    • C96H160N26O31

    • Absent Amino Acids

    • CEFHIMNQW

    • Common Amino Acids

    • DK

    • Mass

    • 2174.48

    • PI

    • 8.4

    • Basic Residues

    • 4

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +1

    • Boman Index

    • -43.93

    • Hydrophobicity

    • -0.71

    • Aliphatic Index

    • 78

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 78.42

    • Polar Residues

    • 5

DRAMP01005

DRAMP01005 chydropathy plot

Comments Information

    • Function

    • Has antifungal activity. Also inhibits HIV-1 reverse transcriptase.

Literature Information

  • ·Literature 1

    • Title

    • Cicerarin, a novel antifungal peptide from the green chickpea.

    • Reference

    • Peptides. 2003 May;24(5):659-663.

    • Author

    • Chu KT, Liu KH, Ng TB.