General Information

    • DRAMP ID

    • DRAMP01006

    • Peptide Name

    • Cicerin (Plant defensin)

    • Source

    • Cicer arietinum (chickpea)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ARCENFADSYRQPPISSSQT

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Mycosphaerella arachidicola, Fusarium oxysporum, Botrytis cinerea (IC50=12 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01006 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01006.

Physicochemical Information

    • Formula

    • C94H145N29O34S

    • Absent Amino Acids

    • GHKLMVW

    • Common Amino Acids

    • S

    • Mass

    • 2257.42

    • PI

    • 6.11

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 4

    • Net Charge

    • 0

    • Boman Index

    • -66.6

    • Hydrophobicity

    • -1.075

    • Aliphatic Index

    • 29.5

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 78.42

    • Polar Residues

    • 8

DRAMP01006

DRAMP01006 chydropathy plot

Comments Information

    • Function

    • Has antifungal activity. Inhibits cell-free translation in rabbit reticulocyte lysate system.

Literature Information

  • ·Literature 1

    • Title

    • Cicerin and arietin, novel chickpea peptides with different antifungal potencies.

    • Reference

    • Peptides. 2003 May;24(5):665-669.

    • Author

    • Cai YD, Liu XJ, Li YX, Xu XB, Chou KC.