General Information

    • DRAMP ID

    • DRAMP01008

    • Peptide Name

    • Antifungal lectin PVAP (Plant defensin)

    • Source

    • Phaseolus vulgaris (Kidney bean)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SNDIYFNFQR

    • Sequence Length

    • 10

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Mycophaerella arachidicola (IC50=9.8 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01008 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01008.

Physicochemical Information

    • Formula

    • C59H82N16O18

    • Absent Amino Acids

    • ACEGHKLMPTVW

    • Common Amino Acids

    • FN

    • Mass

    • 1303.4

    • PI

    • 5.55

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • 0

    • Boman Index

    • -35.12

    • Hydrophobicity

    • -1.05

    • Aliphatic Index

    • 39

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 165.56

    • Polar Residues

    • 4

DRAMP01008

Comments Information

    • Function

    • Has hemagglutinating activity towards rabbit erythrocytes. Has antiproliferative activity towards L1210 tumor cell line with an IC50 of 3.6 µM.

    • Miscellaneous

    • Antifungal, antiproliferative and hemagglutinating activity is abolished by incubatio

Literature Information

  • ·Literature 1

    • Title

    • An antifungal protein from flageolet beans

    • Reference

    • Peptides. 2005 Dec;26(12):2397-2403.

    • Author

    • Xia L, Ng T.B.