General Information

    • DRAMP ID

    • DRAMP01010

    • Peptide Name

    • Lunatusin (Plants)

    • Source

    • Phaseolus lunatus L.(Chinese lima bean)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KTCENLADTFRGPCFATSNC

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal

    • Target Organism

      • Fungi: Fusarium oxysporum, Mycosphaerella arachidicola and Botrytis cinerea.
      • Gram-positive bacteria: Bacillus megaterium, Bacillus subtilis;
      • Gram-negative bacteria: Proteus vulgaris, Mycobacterium phlei.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01010 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01010.

Physicochemical Information

    • Formula

    • C90H140N26O31S3

    • Absent Amino Acids

    • HIMQVWY

    • Common Amino Acids

    • CT

    • Mass

    • 2178.44

    • PI

    • 6.05

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • 0

    • Boman Index

    • -41.11

    • Hydrophobicity

    • -0.34

    • Aliphatic Index

    • 29.5

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.58

    • Polar Residues

    • 10

DRAMP01010

DRAMP01010 chydropathy plot

Comments Information

    • Function

    • It also inhibited proliferation in the breast cancer cell line MCF-7. Lunatusin reduced the activity of HIV-1 reverse transcriptase and it also inhibited translation in a cell-free rabbit reticulocyte lysate system. Its anti-fungal activity was

Literature Information

  • ·Literature 1

    • Title

    • Lunatusin, a trypsin-stable antimicrobial peptide from lima beans (Phaseolus lunatus L.).

    • Reference

    • Peptides. 2005 Nov;26(11):2086-2092.

    • Author

    • Wong JH, Ng TB.