• DRAMP ID

    • DRAMP01012
    • Peptide Name

    • Pg-AMP (Gly-rich; Plants)
    • Source

    • Psidium guajava (Guava)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • RESPSSRMECYEQAERYGYGGYGGGRYGGGYGSGRGQPVGQGVERSHDDNRNQPR
    • Sequence Length

    • 55
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram-, Antimicrobial
    • Target Organism

      • Gram-negative bacteria: Klebsiella sp., Proteus sp., Escherichia coli ATCC 8739 (MIC=72 mg/ml), Klebsiella pneumoniae (MIC=32 mg/ml).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01012 helical wheel diagram
    • Formula

    • C248H373N87O87S2
    • Absent Amino Acids

    • FIKLTW
    • Common Amino Acids

    • G
    • Mass

    • 6992.66
    • PI

    • 8.45
    • Basic Residues

    • 9
    • Acidic Residues

    • 7
    • Hydrophobic Residues

    • 3
    • Boman Index

    • -202.11
    • Hydrophobicity

    • -167.82
    • Aliphatic Index

    • 12.36
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 8940
    • Absorbance 280nm

    • 165.56
    • Polar Residues

    • 28

DRAMP01012

DRAMP01012 chydropathy plot
    • Function

    • Has antibacterial activity against the Gram-negative bacteria. Does not have antifungal activity against the human and plant pathogenic fungi F. oxysporum, A. fumigatus and R. solani.
    • Subunit structure

    • Monomer and homodimer. Might act by homodimer formation.
  • Literature 1
    • Reference

    • Peptides. 2008 Aug;29(8):1271-1279.
    • Author

    • Pelegrini PB, Murad AM, Silva LP, Dos Santos RC, Costa FT, Tagliari PD, Bloch C Jr, Noronha EF, Miller RN, Franco OL.
    • Title

    • Identification of a novel storage glycine-rich peptide from guava (Psidium guajava) seeds with activity against Gram-negative bacteria.