General Information

    • DRAMP ID

    • DRAMP01013

    • Peptide Name

    • PvD1 (P. vulgaris defensin 1; Plants)

    • Source

    • Phaseolus vulgaris (Seeds)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KTCENLADTYKGPCFTTGSCD

    • Sequence Length

    • 21

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Candida albicans, C. parapsilosis, Candida tropicalis, Candida guilliermondii, K. marxiannus, Saccharomyces cerevisiae, Fusarium oxysporum, F. solani, F. lateritium and R. solani.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01013 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01013.

Physicochemical Information

    • Formula

    • C93H144N24O35S3

    • Absent Amino Acids

    • HIMQRVW

    • Common Amino Acids

    • T

    • Mass

    • 2254.49

    • PI

    • 4.56

    • Basic Residues

    • 2

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 3

    • Net Charge

    • -1

    • Boman Index

    • -40.38

    • Hydrophobicity

    • -0.629

    • Aliphatic Index

    • 23.33

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 80.75

    • Polar Residues

    • 12

DRAMP01013

DRAMP01013 chydropathy plot

Comments Information

    • Its activity involves membrane permeabilization, inhibition of medium acifification, and induction of ROS in fungi cells (Curr Microbiol. 2010 Dec 19. 62

    • 1209-1217).

Literature Information

  • ·Literature 1

    • Title

    • Isolation, characterization and cloning of a cDNA encoding a new antifungal defensin from Phaseolus vulgaris L. seeds.

    • Reference

    • Peptides. 2008 Dec;29(12):2090-2100.

    • Author

    • Games PD, Dos Santos IS, Mello EO, Diz MS, Carvalho AO, de Souza-Filho GA, Da Cunha M, Vasconcelos IM, Ferreira Bdos S, Gomes VM.