• DRAMP ID

    • DRAMP01061
    • Peptide Name

    • Antifungal peptide (Cm-p1; Plants)
    • Source

    • Cenchritis muricatus (Beaded periwinkle)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • SRSELIVHQR
    • Sequence Length

    • 10
    • Evidence code

    • Protein level
    • Biological Activity

    • Antifungal, Antimicrobial
    • Target Organism

      • Fungi: Botrytis cinerea (MIC=20 µM), Fusarium oxysporum (MIC=20 µM), Aspergillus niger (MIC=41 µM), Candida albicans 01U (MIC=13 µM), C. albicans 38U (MIC=7 µM), C. parapsilosis (MIC=105 µM), C. neoformans strain L26 (MIC=209 µM), C. neoformans strain L30 (MIC=209 µM), Trichophyton rubrum (MIC=3 µM).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • PDB ID

    • 2MP9 resolved by NMR.
    • DRAMP01061 helical wheel diagram
    • 2MP9-> 
    • Formula

    • C51H89N19O16
    • Absent Amino Acids

    • ACDFGKMNPTWY
    • Common Amino Acids

    • RS
    • Mass

    • 1385.09
    • PI

    • 10.4
    • Basic Residues

    • 3
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 3
    • Boman Index

    • -39.77
    • Hydrophobicity

    • -83
    • Aliphatic Index

    • 107
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP01061

    • Function

    • The synthetic peptide has antifungal activity. Has no antibacterial or cytotoxic activity.
  • Literature 1
    • Reference

    • Biochimie. 2012 Apr;94(4):968-974.
    • Author

    • López-Abarrategui C, Alba A, Silva ON, Reyes-Acosta O, Vasconcelos IM, Oliveira JT, Migliolo L, Costa MP, Costa CR, Silva MR, Garay HE, Dias SC, Franco OL, Otero-González AJ.
    • Title

    • Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus.