General Information

    • DRAMP ID

    • DRAMP01062

    • Peptide Name

    • Putative antimicrobial protein 3 (Cm-p2; Plants)

    • Source

    • Cenchritis muricatus (Beaded periwinkle)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SESILIVHQQQSRSSGS

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01062 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01062.

Physicochemical Information

    • Formula

    • C75H127N25O29

    • Absent Amino Acids

    • ACDFKMNPTWY

    • Common Amino Acids

    • S

    • Mass

    • 1842.98

    • PI

    • 6.47

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +1

    • Boman Index

    • -43.67

    • Hydrophobicity

    • -0.582

    • Aliphatic Index

    • 85.88

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP01062

Comments Information

    • Function

    • This peptide demonstrated the capacity to prevent the development of yeasts and filamentous fungi. Otherwise, Cm-p1 displayed no toxic effects against mammalian cells.

Literature Information

  • ·Literature 1

    • Title

    • Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus.

    • Reference

    • Biochimie. 2012 Apr;94(4):968-974.

    • Author

    • L³pez-Abarrategui C, Alba A, Silva ON, Reyes-Acosta O, Vasconcelos IM, Oliveira JT, Migliolo L, Costa MP, Costa CR, Silva MR, Garay HE, Dias SC, Franco OL, Otero-Gonz¡lez AJ.