• DRAMP ID

    • DRAMP01066
    • Peptide Name

    • Kunitz-type serine protease inhibitor 1 (Xb-KTI; Plants)
    • Source

    • Xanthosoma sagittifolium (Elephant's ear) (Arum sagittifolium)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • PVVDTTGNNPLQQQEEYYV
    • Sequence Length

    • 19
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.21520894]Gram-negative bacterium: Salmonella typhimurium ATCC 14028 (MIC=10 µM).
    • Hemolytic activity

      • [Ref:21520894]7% hemolytic activity at 250 μg/mL against human erythrocytes
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01066 helical wheel diagram
    • Formula

    • C96H144N24O35
    • Absent Amino Acids

    • ACFHIKMRSW
    • Common Amino Acids

    • QV
    • Mass

    • 2515.58
    • PI

    • 3.42
    • Basic Residues

    • 0
    • Acidic Residues

    • 3
    • Hydrophobic Residues

    • 4
    • Boman Index

    • -39.68
    • Hydrophobicity

    • -101.05
    • Aliphatic Index

    • 66.32
    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?
    • Extinction Coefficient Cystines

    • 2980
    • Absorbance 280nm

    • 165.56
    • Polar Residues

    • 7

DRAMP01066

DRAMP01066 chydropathy plot
    • Function

    • Serine protease inhibitor. Displays antimicrobial activity against the Gram-negative bacterium S. typhimurium ATCC 14028. Displays a weak hemolytic activity.
  • Literature 1
    • Reference

    • J Nat Prod. 2011 May 27;74(5):969-975.
    • Author

    • Lima TB, Silva ON, Migliolo L, Souza-Filho CR, Gonçalves EG, Vasconcelos IM, Oliveira JT, Amaral AC, Franco OL.
    • Title

    • A Kunitz proteinase inhibitor from corms of Xanthosoma blandum with bactericidal activity.