General Information

    • DRAMP ID

    • DRAMP01066

    • Peptide Name

    • Kunitz-type serine protease inhibitor 1 (Xb-KTI; Plants)

    • Source

    • Xanthosoma sagittifolium (Elephant's ear) (Arum sagittifolium)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • PVVDTTGNNPLQQQEEYYV

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.21520894]Gram-negative bacterium: Salmonella typhimurium ATCC 14028 (MIC=10 µM).

    • Hemolytic Activity

      • [Ref.21520894] No hemolytic activity was observed for Xb-KTI. The peptide induced a hemolysis of 12% at the highest concentration of 250 μg/mL. Values(OD540) were normalized against 100% lysed erythrocytes (0.1% Triton X-100) and PDB (untreated control)

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01066 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01066.

Physicochemical Information

    • Formula

    • C96H144N24O35

    • Absent Amino Acids

    • ACFHIKMRSW

    • Common Amino Acids

    • QV

    • Mass

    • 2194.34

    • PI

    • 3.57

    • Basic Residues

    • 0

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 4

    • Net Charge

    • -3

    • Boman Index

    • -39.68

    • Hydrophobicity

    • -1.011

    • Aliphatic Index

    • 66.32

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 165.56

    • Polar Residues

    • 7

DRAMP01066

DRAMP01066 chydropathy plot

Comments Information

    • Function

    • Serine protease inhibitor. Displays antimicrobial activity against the Gram-negative bacterium S. typhimurium ATCC 14028. Displays a weak hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • A Kunitz proteinase inhibitor from corms of Xanthosoma blandum with bactericidal activity.

    • Reference

    • J Nat Prod. 2011 May 27;74(5):969-975.

    • Author

    • Lima TB, Silva ON, Migliolo L, Souza-Filho CR, Gonçalves EG, Vasconcelos IM, Oliveira JT, Amaral AC, Franco OL.