General Information

    • DRAMP ID

    • DRAMP01067

    • Peptide Name

    • Coccinin (Plant defensin)

    • Source

    • Phaseolus coccineus (Scarlet runner bean) (Phaseolus multiflorus)

    • Family

    • Belongs to the DEFL family

    • Gene

    • Not found

    • Sequence

    • KQTENLADTY

    • Sequence Length

    • 10

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal, Antiviral

    • Target Organism

      • Fungi: Fusarium oxysporum (IC50=81±7 µM), Mycosphaerella arachidicola (IC50=75±5 µM), Physalospora piricola (IC50=89±4 µM), Rhizoctomia solani (IC50=134±2 µM), Botrytis cinerea (IC50=109±5 µM), Coprinus comatus (IC50=122±7 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01067 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01067.

Physicochemical Information

    • Formula

    • C50H79N13O20

    • Absent Amino Acids

    • CFGHIMPRSVW

    • Common Amino Acids

    • T

    • Mass

    • 1182.25

    • PI

    • 4.37

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 2

    • Net Charge

    • -1

    • Boman Index

    • -31.81

    • Hydrophobicity

    • -1.5

    • Aliphatic Index

    • 49

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 165.56

    • Polar Residues

    • 4

DRAMP01067

Comments Information

    • Function

    • Has strong antifungal activity. Inhibits the proliferation of leukemia cells in vitro. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase (IC50=41 µM). Lacks mitogenic activity towards murine splenocytes.

Literature Information

  • ·Literature 1

    • Title

    • Coccinin, an antifungal peptide with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from large scarlet runner beans.

    • Reference

    • Peptides. 2004 Dec;25(12):2063-2068.

    • Author

    • Ngai PH, Ng TB.