• DRAMP ID

    • DRAMP01067
    • Peptide Name

    • Coccinin (Plant defensin)
    • Source

    • Phaseolus coccineus (Scarlet runner bean) (Phaseolus multiflorus)
    • Family

    • Belongs to the DEFL family
    • Gene

    • N/A
    • Sequence

    • KQTENLADTY
    • Sequence Length

    • 10
    • Evidence code

    • Protein level
    • Biological Activity

    • Antifungal, Antiviral, Antimicrobial
    • Target Organism

      • Fungi: Fusarium oxysporum (IC50=81±7 µM), Mycosphaerella arachidicola (IC50=75±5 µM), Physalospora piricola (IC50=89±4 µM), Rhizoctomia solani (IC50=134±2 µM), Botrytis cinerea (IC50=109±5 µM), Coprinus comatus (IC50=122±7 µM).
    • Hemolytic Activity

      • N/A
    • Cytotoxicity

    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • N-terminal modification

    • C-terminal modification

    • Other modifications

    • Stereochemistry

    • Structure

    • N/A
    • Structure Description

    • N/A
    • DRAMP01067 helical wheel diagram
    • Formula

    • C50H79N13O20
    • Absent Amino Acids

    • CFGHIMPRSVW
    • Common Amino Acids

    • T
    • Mass

    • 1342.97
    • PI

    • 4.18
    • Basic Residues

    • 1
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 2
    • Boman Index

    • -31.81
    • Hydrophobicity

    • -150
    • Aliphatic Index

    • 49
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 165.56
    • Polar Residues

    • 4

DRAMP01067

    • Function

    • Has strong antifungal activity. Inhibits the proliferation of leukemia cells in vitro. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase (IC50=41 µM). Lacks mitogenic activity towards murine splenocytes.
  • Literature 1
    • Reference

    • Peptides. 2004 Dec;25(12):2063-2068.
    • Author

    • Ngai PH, Ng TB.
    • Title

    • Coccinin, an antifungal peptide with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from large scarlet runner beans.