• DRAMP ID

    • DRAMP01081
    • Peptide Name

    • Alyteserin-1a (toads, amphibians, animals)
    • Source

    • Alytes obstetricans (European midwife toad)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • GLKDIFKAGLGSLVKGIAAHVAN
    • Sequence Length

    • 23
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.19463738]Gram-negative bacterium: Escherichia coli (MIC=25 µM).
    • Hemolytic activity

      • [Ref:19463738]11% hemolytic activity at 100 μM against human erythrocytes
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01081 helical wheel diagram
    • Formula

    • C104H175N29O28
    • Absent Amino Acids

    • CEMPQRTWY
    • Common Amino Acids

    • AG
    • Mass

    • 2672.34
    • PI

    • 10.51
    • Basic Residues

    • 4
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 12
    • Boman Index

    • 6.59
    • Hydrophobicity

    • 63.04
    • Aliphatic Index

    • 127.39
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 6

DRAMP01081

DRAMP01081 chydropathy plot
    • Function

    • The alyteserin-1 peptides show selective growth inhibitory activity against the Gram-negative bacterium Escherichia coli. The hemolytic activity against human erythrocytes of all peptides tested is relatively weak.
    • Structural similarity

    • The alyteserin-1 peptides show limited structural similarity to the ascaphins from the skins of frogs of the family Leiopelmatidae.
  • Literature 1
    • Reference

    • Peptides. 2009 Jun;30(6):1069-1073.
    • Author

    • Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC.
    • Title

    • The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae).