• DRAMP ID

    • DRAMP01082
    • Peptide Name

    • Alyteserin-2a (toads, amphibians, animals)
    • Source

    • Alytes obstetricans (European midwife toad)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • ILGKLLSTAAGLLSNL
    • Sequence Length

    • 16
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Cytotoxicity, Anti-Gram+, Antimicrobial
    • Target Organism

      • [Ref.19463738]Gram-positive bacterium: Staphylococcus aureus (MIC=50 µM).
    • Hemolytic activity

      • [Ref:19463738]LC50=135μM against human erythrocytes
    • Binding Target

    • Unknown
    • Structure

    • Alpha helix
    • Structure Description

    • It is helical in 50% TFE.
    • DRAMP01082 helical wheel diagram
    • Formula

    • C72H130N18O21
    • Absent Amino Acids

    • CDEFHMPQRVWY
    • Common Amino Acids

    • L
    • Mass

    • 1851.69
    • PI

    • 9.7
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Boman Index

    • 18.38
    • Hydrophobicity

    • 127.5
    • Aliphatic Index

    • 183.13
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 6

DRAMP01082

    • Function

    • The alyteserin-2a is more potent against the Gram-positive bacteria Staphylococcus aureus. The hemolytic activity against human erythrocytes of all peptides tested is relatively weak.
    • Structural similarity

    • Alyteserin-2a and alyteserin-2b and -2c show limited sequence identity with bombinin H6, present in the skins of frogs of the family Bombinatoridae.
  • Literature 1
    • Reference

    • Peptides. 2009 Jun;30(6):1069-1073.
    • Author

    • Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC.
    • Title

    • The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae).