• DRAMP ID

    • DRAMP01083
    • Peptide Name

    • Alyteserin-1b (toads, amphibians, animals)
    • Source

    • Alytes obstetricans (European midwife toad)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GLKEIFKAGLGSLVKGIAAHVAN
    • Sequence Length

    • 23
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-
    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=25 µM).
    • Hemolytic Activity

      • [Ref:19463738] LC50 = 210 μM against human erthrocytes.
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • α-Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L (to be determined)
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01083 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01083.
    • Formula

    • C105H177N29O28
    • Absent Amino Acids

    • CDMPQRTWY
    • Common Amino Acids

    • AG
    • Mass

    • 2293.74
    • PI

    • 9.7
    • Basic Residues

    • 4
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +3
    • Boman Index

    • 8.5
    • Hydrophobicity

    • 0.63
    • Aliphatic Index

    • 127.39
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 6

DRAMP01083

DRAMP01083 chydropathy plot
    • Function

    • Amtimicrobial peptide. (By similarity)
  • ·Literature 1
    • Title

    • The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae).
    • Reference

    • Peptides. 2009 Jun;30(6):1069-1073.
    • Author

    • Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC.