• DRAMP ID

    • DRAMP01090
    • Peptide Name

    • Alyteserin-2Ma (toads, amphibians, animals)
    • Source

    • Alytes maurus (Midwife toad)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • FIGKLISAASGLLSHL
    • Sequence Length

    • 16
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=38.4 µM) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=9.5 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Serum or Protease Type

    • Not available
    • Stability Data

    • Not available
    • Assay

    • Not available
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • α-Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01090 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01090.
    • Formula

    • C76H127N19O20
    • Absent Amino Acids

    • CDEMNPQRTVWY
    • Common Amino Acids

    • L
    • Mass

    • 1626.96
    • PI

    • 8.76
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +2
    • Boman Index

    • 17.59
    • Hydrophobicity

    • 1.269
    • Aliphatic Index

    • 158.75
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 5

DRAMP01090

    • Function

    • Has antibacterial activity against the Gram-negative bacteria E. coli and Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 150 microM.
  • ·Literature 1
    • Title

    • Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions.
    • Reference

    • Toxicon. 2012 Nov;60(6):967-981.
    • Author

    • König E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C.