• DRAMP ID

    • DRAMP01090
    • Peptide Name

    • Alyteserin-2Ma (toads, amphibians, animals)
    • Source

    • Alytes maurus (Midwife toad)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • FIGKLISAASGLLSHL
    • Sequence Length

    • 16
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-, Antimicrobial
    • Target Organism

      • Gram-negative bacterium: Escherichia coli NCTC 10418 (MIC=38.4 µM) and Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=9.5 µM).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01090 helical wheel diagram
    • Formula

    • C76H127N19O20
    • Absent Amino Acids

    • CDEMNPQRTVWY
    • Common Amino Acids

    • L
    • Mass

    • 1894.71
    • PI

    • 9.7
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Boman Index

    • 17.59
    • Hydrophobicity

    • 126.88
    • Aliphatic Index

    • 158.75
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 5

DRAMP01090

    • Function

    • Has antibacterial activity against the Gram-negative bacteria E. coli and Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 150 microM.
  • Literature 1
    • Reference

    • Toxicon. 2012 Nov;60(6):967-981.
    • Author

    • König E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C.
    • Title

    • Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions.