General Information

    • DRAMP ID

    • DRAMP01091

    • Peptide Name

    • Alyteserin-2Mb (toads, amphibians, animals)

    • Source

    • Alytes maurus (Midwife toad)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ILGAIIPLVSGLLSHL

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=19.3 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • α-Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01091 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01091.

Physicochemical Information

    • Formula

    • C77H134N18O19

    • Absent Amino Acids

    • CDEFKMNQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1616.02

    • PI

    • 6.74

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +1

    • Boman Index

    • 35.63

    • Hydrophobicity

    • 1.956

    • Aliphatic Index

    • 219.38

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01091

Comments Information

    • Function

    • Has antibacterial activity against the Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 310 microM.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions.

    • Reference

    • Toxicon. 2012 Nov;60(6):967-981.

    • Author

    • König E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C.