• DRAMP ID

    • DRAMP01091
    • Peptide Name

    • Alyteserin-2Mb (toads, amphibians, animals)
    • Source

    • Alytes maurus (Midwife toad)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • ILGAIIPLVSGLLSHL
    • Sequence Length

    • 16
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Antifungal, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus NCTC 10788 (MIC=19.3 µM).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01091 helical wheel diagram
    • Formula

    • C77H134N18O19
    • Absent Amino Acids

    • CDEFKMNQRTWY
    • Common Amino Acids

    • L
    • Mass

    • 1883.78
    • PI

    • 7.55
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 10
    • Boman Index

    • 35.63
    • Hydrophobicity

    • 195.63
    • Aliphatic Index

    • 219.38
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP01091

    • Function

    • Has antibacterial activity against the Gram-positive bacteria S. aures. It only inhibits C. albicans at very high concentration of 310 microM.
  • Literature 1
    • Reference

    • Toxicon. 2012 Nov;60(6):967-981.
    • Author

    • König E, Zhou M, Wang L, Chen T, Bininda-Emonds OR, Shaw C.
    • Title

    • Antimicrobial peptides and alytesin are co-secreted from the venom of the Midwife toad, Alytes maurus (Alytidae, Anura): Implications for the evolution of frog skin defensive secretions.