General Information

    • DRAMP ID

    • DRAMP01093

    • Peptide Name

    • Bombinin GH-1L (bombinin H isomers; toads, amphibians, animals)

    • Source

    • Bombina orientalis (Oriental fire-bellied toad)

    • Family

    • Belongs to the bombinin family

    • Gene

    • Not found

    • Sequence

    • IIGPVLGLVGKPLESLLE

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • GH-1L does not display any microbicidal activity against all the microorganisms tested.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01093 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01093.

Physicochemical Information

    • Formula

    • C87H151N19O24

    • Absent Amino Acids

    • ACDFHMNQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1847.27

    • PI

    • 4.53

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 9

    • Net Charge

    • -1

    • Boman Index

    • 22.77

    • Hydrophobicity

    • 1.128

    • Aliphatic Index

    • 183.89

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01093

DRAMP01093 chydropathy plot

Comments Information

    • Function

    • Bombinins GH-1D showes only 2.5% hemolysis at 30 µM concentration.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Structure-Function: relationships in bombinins H, antimicrobial peptides from Bombina skin secretions.

    • Reference

    • Peptides. 2000 Nov;21(11):1673-1679.

    • Author

    • Mangoni ML, Grovale N, Giorgi A, Mignogna G, Simmaco M, Barra D.