• DRAMP ID

    • DRAMP01096
    • Peptide Name

    • Bombinin-like peptide 2 (BLP-2; toads, amphibians, animals)
    • Source

    • Bombina orientalis (Oriental fire-bellied toad)
    • Family

    • Belongs to the bombinin family
    • Gene

    • Unknown
    • Sequence

    • GIGSAILSAGKSALKGLAKGLAEHFAN
    • Sequence Length

    • 27
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antifungal, Anti-Gram-, Antimicrobial
    • Target Organism

      • [Ref.1744108]Gram-negative bacterium: 58% inhibition Neisseria meningitidis 118V C (MIC=20 µg/ml), 98% inhibition Neisseria meningitidis 15240 IAI (MIC=20 µg/ml), 98% inhibition Neisseria meningitidis 126E IC1 (MIC=20 µg/ml), 97% inhibition Neisseria gonorrhoeoe F62 (MIC=20 µg/ml), 99% inhibition Neisseria Iactamica 15323 (MIC=20 µg/ml), 100% inhibition Neisseria Iactamica 15215A (MIC=20 µg/ml), 95% inhibition Neisseria cinerea 15461 (MIC=20 µg/ml).
    • Hemolytic activity

      • [Ref:1744108]Non-hemolytic activity
    • Binding Target

    • Unknown
    • Structure

    • Alpha helix
    • Structure Description

    • Unknown
    • DRAMP01096 helical wheel diagram
    • Formula

    • C115H193N33O34
    • Absent Amino Acids

    • CDMPQRTVWY
    • Common Amino Acids

    • A
    • Mass

    • 3045.97
    • PI

    • 10.51
    • Basic Residues

    • 4
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 13
    • Boman Index

    • 3.1
    • Hydrophobicity

    • 42.59
    • Aliphatic Index

    • 108.89
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 9

DRAMP01096

DRAMP01096 chydropathy plot
    • Function

    • Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria.
    • Tissue specificity

    • Expressed by the skin glands.
  • Literature 1
    • Reference

    • J. Biol. Chem. 1991; 266: 23103-23111.
    • Author

    • Gibson BW, Tang D, Mandrell R, Kelly M, Spindel ER.
    • Title

    • Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis.