General Information

    • DRAMP ID

    • DRAMP01099

    • Peptide Name

    • Bombinin-like peptide 4 (BLP-4; toads, amphibians, animals)

    • Source

    • Bombina orientalis (Oriental fire-bellied toad)

    • Family

    • Belongs to the bombinin family

    • Gene

    • Not found

    • Sequence

    • GIGAAILSAGKSIIKGLANGLAEHF

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.1744108]Gram-negative bacteria: Neisseria meningitidis, Neisseria gonorrhoeoe, Neisseria Iactamica, Neisseria cinerea.

    • Hemolytic Activity

      • [Ref:1744108]Non-hemolytic activity

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01099 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01099.

Physicochemical Information

    • Formula

    • C109H182N30O31

    • Absent Amino Acids

    • CDMPQRTVWY

    • Common Amino Acids

    • AG

    • Mass

    • 2408.83

    • PI

    • 8.6

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +2

    • Boman Index

    • 15.16

    • Hydrophobicity

    • 0.784

    • Aliphatic Index

    • 129.2

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP01099

DRAMP01099 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis.

    • Reference

    • J Biol Chem. 1991 Dec 5;266(34):23103-23111.

    • Author

    • Gibson BW, Tang DZ, Mandrell R, Kelly M, Spindel ER.