General Information

    • DRAMP ID

    • DRAMP01100

    • Peptide Name

    • Bombinin-like peptide 1 (Contains: Bombinin H; toads, amphibians, animals)

    • Source

    • Bombina variegata (Yellow-bellied toad)

    • Family

    • Belongs to the bombinin family

    • Gene

    • Not found

    • Sequence

    • GIGGALLSAAKVGLKGLAKGLAEHFAN

    • Sequence Length

    • 27

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.1712299]Gram-positive bacteria: Staphylococcus species;
      • Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Pseudomonas maltophilia, Alcaligenes denitrificans.

    • Hemolytic Activity

      • [Ref:8223491]Has low hemolytic activity

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01100 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01100.

Physicochemical Information

    • Formula

    • C116H195N33O32

    • Absent Amino Acids

    • CDMPQRTWY

    • Common Amino Acids

    • AG

    • Mass

    • 2564.03

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +3

    • Boman Index

    • 14.88

    • Hydrophobicity

    • 0.6

    • Aliphatic Index

    • 119.63

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP01100

DRAMP01100 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity, but low hemolytic activity. Preliminary evidence indicates that this peptide does not lyse and thus kill the bacteria by its antimicrobial activity. Bombinin H has antibacterial and hemolytic activity.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • A family of bombinin-related peptides from the skin of Bombina variegata.

    • Reference

    • Eur J Biochem. 1991 Jul 1;199(1):217-222.

    • Author

    • Simmaco M, Barra D, Chiarini F, Noviello L, Melchiorri P, Kreil G, Richter K.
  • ·Literature 2

    • Title

    • Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.

    • Reference

    • EMBO J. 1993 Dec;12(12):4829-4832.

    • Author

    • Mignogna G, Simmaco M, Kreil G, Barra D.