General Information

    • DRAMP ID

    • DRAMP01103

    • Peptide Name

    • Maximin-S2 (chain of Maximins-S type B/C; toads, amphibians, animals)

    • Source

    • Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)

    • Family

    • Belongs to the bombinin family

    • Gene

    • Not found

    • Sequence

    • GSNKGFNFMVDMIQALSN

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref:15649437]Non-hemolytic activity

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01103 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01103.

Physicochemical Information

    • Formula

    • C85H133N23O27S2

    • Absent Amino Acids

    • CEHPRTWY

    • Common Amino Acids

    • N

    • Mass

    • 1973.25

    • PI

    • 5.84

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • 0

    • Boman Index

    • -18.3

    • Hydrophobicity

    • -0.006

    • Aliphatic Index

    • 65

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP01103

DRAMP01103 chydropathy plot

Comments Information

    • Function

    • Maximin-S2 has an activity against mycoplasma but has no activity against common Gram-positive and Gram-negative bacteria nor fungi. Has no hemolytic activity. Tissue specificity

Literature Information

  • ·Literature 1

    • Title

    • Maximins S, a novel group of antimicrobial peptides from toad Bombina maxima.

    • Reference

    • Biochem Biophys Res Commun. 2005 Feb 18;327(3):945-951.

    • Author

    • Wang T, Zhang J, Shen JH, Jin Y, Lee WH, Zhang Y.