General Information

    • DRAMP ID

    • DRAMP01116

    • Peptide Name

    • Maximin-10 (toads, amphibians, animals)

    • Source

    • Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)

    • Family

    • Belongs to the bombinin family

    • Gene

    • Not found

    • Sequence

    • GIGGALLSAGKSALKGLAKGLAEHFAS

    • Sequence Length

    • 27

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

      • [Swiss_Prot Entry Q58T45]Yeast: Candida albicans

    • Hemolytic Activity

      • [Ref:11835991]Little hemolytic activity at 50 μg/ml against red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01116 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01116.

Physicochemical Information

    • Formula

    • C113H190N32O33

    • Absent Amino Acids

    • CDMNPQRTVWY

    • Common Amino Acids

    • AG

    • Mass

    • 2524.95

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +3

    • Boman Index

    • 10.68

    • Hydrophobicity

    • 0.515

    • Aliphatic Index

    • 108.89

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 9

DRAMP01116

DRAMP01116 chydropathy plot

Comments Information

    • Function

    • Maximin-10 shows antimicrobial activity against bacteria and against the fungus C. albicans. It has little hemolytic activity (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.

    • Reference

    • Eur J Immunol. 2005 Apr;35(4):1220-1229.

    • Author

    • Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.
  • ·Literature 2

    • Title

    • Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.

    • Reference

    • Peptides. 2002 Mar;23(3):427-435.

    • Author

    • Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y.