General Information
-
DRAMP ID
- DRAMP01125
-
Peptide Name
- Maximin-H3 (Toads, amphibians, animals)
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Source
- Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
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Family
- Belongs to the bombinin family
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Gene
- Not found
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Sequence
- ILGPVLGLVGNALGGLIKKI
-
Sequence Length
- 20
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.11835991] Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=20 μg/ml);
- Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=10 μg/ml), Bacillus pyocyaneus CMCCB 1010 (MIC=20 μg/ml);
- Fungi: Candida albicans ATCC 2002 (MIC=5 μg/ml).
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Hemolytic Activity
-
- [Ref:11835991]90–100% hemolytic activity at 50 μg/ml against rabbit red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Cell membrane
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP01125_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C92H165N23O22
Absent Amino Acids
- CDEFHMQRSTWY
Common Amino Acids
- GL
Mass
- 1945.46
PI
- 10
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +2
-
Boman Index
- 36.21
Hydrophobicity
- 1.39
Aliphatic Index
- 190
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 6
DRAMP01125
Comments Information
Function
- Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Shows strong hemolytic activity.
Literature Information
- ·Literature 1
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Title
- Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.
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Pubmed ID
- 15770703
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Reference
- Eur J Immunol. 2005 Apr;35(4):1220-9.
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Author
- Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.
- ·Literature 2
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Title
- Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
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Pubmed ID
- 11835991
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Reference
- Peptides. 2002 Mar;23(3):427-435.
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Author
- Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y.