• DRAMP ID

    • DRAMP01126
    • Peptide Name

    • Maximin-H4 (Toads, amphibians, animals)
    • Source

    • Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
    • Family

    • Belongs to the bombinin family
    • Gene

    • Not found
    • Sequence

    • ILGPVISKIGGVLGGLLKNL
    • Sequence Length

    • 20
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.11835991] Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=12 μg/ml);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=6 μg/ml), Bacillus pyocyaneus CMCCB 1010 (MIC=12 μg/ml).
      • Yeast: Candida albicans ATCC 2002 (MIC=6 μg/ml).
    • Hemolytic Activity

      • [Ref:11835991]90–100% hemolytic activity at 50 μg/ml against rabbit red blood cells
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Cell membrane
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01126 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C92H165N23O23
    • Absent Amino Acids

    • ACDEFHMQRTWY
    • Common Amino Acids

    • GL
    • Mass

    • 1961.46
    • PI

    • 10
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +2
    • Boman Index

    • 31
    • Hydrophobicity

    • 1.26
    • Aliphatic Index

    • 185
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 7

DRAMP01126

DRAMP01126 chydropathy plot
    • Function

    • Antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Shows strong hemolytic activity.
  • ·Literature 1
    • Title

    • Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.
    • Reference

    • Eur J Immunol. 2005 Apr;35(4):1220-9.
    • Author

    • Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y.
  • ·Literature 2
    • Title

    • Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
    • Reference

    • Peptides. 2002 Mar;23(3):427-435.
    • Author