General Information

    • DRAMP ID

    • DRAMP01127

    • Peptide Name

    • Maximin-H5 (toads, amphibians, animals)

    • Source

    • Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)

    • Family

    • Belongs to the bombinin family

    • Gene

    • Not found

    • Sequence

    • ILGPVLGLVSDTLDDVLGIL

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01127 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01127.

Physicochemical Information

    • Formula

    • C93H160N20O29

    • Absent Amino Acids

    • ACEFHKMNQRWY

    • Common Amino Acids

    • L

    • Mass

    • 2022.41

    • PI

    • 3.42

    • Basic Residues

    • 0

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 11

    • Net Charge

    • -3

    • Boman Index

    • 22.17

    • Hydrophobicity

    • 1.48

    • Aliphatic Index

    • 199.5

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01127

DRAMP01127 chydropathy plot

Comments Information

    • Comment

    • A arginine mutant (i.e. 3D to 3R) was found to be HIV inhibitory (Wang G et al. 2010 Antimicrob. Agents Chemother. 54

Literature Information

  • ·Literature 1

    • Title

    • An anionic antimicrobial peptide from toad Bombina maxima.

    • Reference

    • Biochem Biophys Res Commun 2002 Jul 26;295(4):796-799.

    • Author

    • Lai R, Liu H, Hui Lee W, Zhang Y.