General Information

    • DRAMP ID

    • DRAMP01138

    • Peptide Name

    • Maximin-H16 (toads, amphibians, animals)

    • Source

    • Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)

    • Family

    • Belongs to the bombinin family

    • Gene

    • Not found

    • Sequence

    • ILGPVLSLVGNALGGLIKKI

    • Sequence Length

    • 20

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

      • [Swiss_Prot Entry Q58T93]Yeast: Candida albicans

    • Hemolytic Activity

      • [Ref:11835991]90–100% hemolytic activity at 50 μg/ml against rabbit red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01138 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01138.

Physicochemical Information

    • Formula

    • C93H167N23O23

    • Absent Amino Acids

    • CDEFHMQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1975.49

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 31.87

    • Hydrophobicity

    • 1.37

    • Aliphatic Index

    • 190

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP01138

DRAMP01138 chydropathy plot

Comments Information

    • Shows strong hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.

    • Reference

    • Eur J Immunol. 2005 Apr;35(4):1220-1229.

    • Author

    • Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W.
  • ·Literature 2

    • Title

    • Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.

    • Reference

    • Peptides. 2002 Mar;23(3):427-435.

    • Author

    • Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y.