General Information

    • DRAMP ID

    • DRAMP01140

    • Peptide Name

    • Uperin-2.2 (toads, amphibians, animals)

    • Source

    • Uperoleia inundata (Floodplain toadlet)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GFVDLAKKVVGGIRNALGI

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Bacillus cereus, Leuconostoc mesenteroides, L. innocua, Micrococcus luteus, Staphylococcus aureus and Streptococcus uberis.
      • Gram-negative bacteria: Pasteurella haemolytica, Escherichia coli.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01140 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01140.

Physicochemical Information

    • Formula

    • C88H151N25O23

    • Absent Amino Acids

    • CEHMPQSTWY

    • Common Amino Acids

    • G

    • Mass

    • 1927.32

    • PI

    • 9.99

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +2

    • Boman Index

    • 0.78

    • Hydrophobicity

    • 0.774

    • Aliphatic Index

    • 138.42

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01140

DRAMP01140 chydropathy plot

Comments Information

    • Function

    • Shows a weak antibacterial activity.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • Novel uperin peptides from the dorsal glands of the australian floodplain toadlet Uperoleia inundata.

    • Reference

    • Aust. J. Chem. 1996; 49:475-484.

    • Author

    • Bradford AM, Raftery MJ, Bowie JH, Tyler MJ, Wallace JC, Adams GW, Severini C.