• DRAMP ID

    • DRAMP01151
    • Peptide Name

    • Uperin-3.5 (toads, amphibians, animals)
    • Source

    • Uperoleia mjobergii (Australian toadlet)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • GVGDLIRKAVSVIKNIV
    • Sequence Length

    • 17
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=25 µg/ml), Lactococcus lactis (MIC=3 µg/ml), Listeria innocua (MIC=25 µg/ml), Micrococcus luteus (MIC=12.5 µg/ml), Staphylococcus aureus (MIC=50 µg/ml), Staphylococcus epidermidis (MIC=12.5 µg/ml), Streptococcus uberis (MIC=12.5 µg/ml).(Ref.2)
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01151 helical wheel diagram
    • Formula

    • C80H145N23O22
    • Absent Amino Acids

    • CEFHMPQTWY
    • Common Amino Acids

    • V
    • Mass

    • 2066.76
    • PI

    • 10.79
    • Basic Residues

    • 3
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 9
    • Boman Index

    • -5.25
    • Hydrophobicity

    • 88.24
    • Aliphatic Index

    • 165.88
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP01151

    • Function

    • Shows antibacterial activity.
    • Tissue specificity

    • Expressed by the skin dorsal glands.
  • Literature 1
    • Reference

    • Aust. J. Chem. 1996; 49:475-484.
    • Author

    • Bradford AM, Raftery MJ, Bowie JH, Tyler MJ, Wallace JC, Adams GW, Severini C.
    • Title

    • Novel uperin peptides from the dorsal glands of the australian floodplain toadlet Uperoleia inundata.
  • Literature 2
    • Reference

    • Peptides. 2004 Jun;25(6):1035-1054.
    • Author

    • Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.
    • Title

    • Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.