General Information

    • DRAMP ID

    • DRAMP01153

    • Peptide Name

    • Ala4-uperin 3.6 (toads, amphibians, animals)

    • Source

    • Uperoleia mjobergii (Australian toadlet)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GVIAAAKKVVNVLKNLF

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=25 µg/ml), Leuconostoc lactis (MIC=3 µg/ml), Listeria innocua (MIC=25 µg/ml), Micrococcus luteus (MIC=12 µg/ml), Staphylococcus aureus (MIC=25 µg/ml), Staphylococcus epidermidis (MIC=12 µg/ml), Streptococcus uberis (MIC=25 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01153 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01153.

Physicochemical Information

    • Formula

    • C84H146N22O20

    • Absent Amino Acids

    • CDEHMPQRSTWY

    • Common Amino Acids

    • V

    • Mass

    • 1784.22

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • 10.34

    • Hydrophobicity

    • 1.059

    • Aliphatic Index

    • 154.71

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP01153

Comments Information

    • Function

    • Shows antibacterial activity gaginst several Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii.

    • Reference

    • J Pept Res. 1999 Aug;54(2):137-145.

    • Author

    • Chia BC, Carver JA, Mulhern TD, Bowie JH.