• DRAMP ID

    • DRAMP01153
    • Peptide Name

    • Ala4-uperin 3.6 (toads, amphibians, animals)
    • Source

    • Uperoleia mjobergii (Australian toadlet)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • GVIAAAKKVVNVLKNLF
    • Sequence Length

    • 17
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknown
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=25 µg/ml), Leuconostoc lactis (MIC=3 µg/ml), Listeria innocua (MIC=25 µg/ml), Micrococcus luteus (MIC=12 µg/ml), Staphylococcus aureus (MIC=25 µg/ml), Staphylococcus epidermidis (MIC=12 µg/ml), Streptococcus uberis (MIC=25 µg/ml).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP01153 helical wheel diagram
    • Formula

    • C84H146N22O20
    • Absent Amino Acids

    • CDEHMPQRSTWY
    • Common Amino Acids

    • V
    • Mass

    • 2069.81
    • PI

    • 11.1
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 11
    • Boman Index

    • 10.34
    • Hydrophobicity

    • 105.88
    • Aliphatic Index

    • 154.71
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP01153

    • Function

    • Shows antibacterial activity gaginst several Gram-positive bacteria.
  • Literature 1
    • Reference

    • J Pept Res. 1999 Aug;54(2):137-145.
    • Author

    • Chia BC, Carver JA, Mulhern TD, Bowie JH.
    • Title

    • The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii.