• • DRAMP ID

  • DRAMP01169

• • Peptide Name

  • Distinctin 1 (Frogs, amphibians, animals)

• • Source

  • Phyllomedusa distincta (Tree frog)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • ENREVPPGFTALIKTLRKCKII

• • Sequence Length

  • 22

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial

• • Target Organism

  • • Note: Distinctin chain 1 links to Distinctin chain 2 to form a heterodimeric peptide to exert antibacterial function.
    • Gram-positive bacteria: Enterococcus faecalis (MIC=14.5 µM), Staphylococcus aureus (MIC=28.0 µM);
    • Gram-negative bacteria: Pseudomonas aeruginosa (MIC=28.0 µM), Escherichia coli (MIC=14.5 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • There is an intermolecular disulphide bridge between Distinctin chain 1 (Cys19) and Distinctin chain 2 (Cys22). There is an intermolecular disulphide bridge between Distinctin chain 1 (Cys19) and Distinctin chain 2 (Cys22).

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01169.

DRAMP01169

• • Comment

  • No comments found on DRAMP database

• ·Literature 1

• • Title

  • Production and isotope labeling of antimicrobial peptides in Escherichia coli by means of a novel fusion partner that enables high-yield insoluble expression and fast purification.

• • Pubmed ID

  • 19189273

• • Reference

  • J Pept Sci. 2009 Apr;15(4):278-284.

• • Author

  • Vidovic V, Prongidi-Fix L, Bechinger B, Werten S.