General Information

    • DRAMP ID

    • DRAMP01171

    • Peptide Name

    • Ocellatin-1 (Frogs, amphibians, animals)

    • Source

    • Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GVVDILKGAGKDLLAHLVGKISEKV

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Swiss_Prot Entry P83951]Gram-negative bacterium: Escherichia coli

    • Hemolytic Activity

      • [Ref:15648972]Show hemolytic activity against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01171 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01171.

Physicochemical Information

    • Formula

    • C116H203N31O33

    • Absent Amino Acids

    • CFMNPQRTWY

    • Common Amino Acids

    • GKLV

    • Mass

    • 2560.08

    • PI

    • 8.44

    • Basic Residues

    • 5

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • -1.45

    • Hydrophobicity

    • 0.516

    • Aliphatic Index

    • 148

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01171

DRAMP01171 chydropathy plot

Comments Information

    • Function

    • Has hemolytic activity against human erythrocytes and antibacterial activity against the Gram-negative bacterium E. coli.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • Ocellatins: new antimicrobial peptides from the skin secretion of the South American frog Leptodactylus ocellatus (Anura: Leptodactylidae).

    • Reference

    • Protein J. 2004 Nov;23(8):501-508.

    • Author

    • Nascimento AC, Zanotta LC, Kyaw CM, Schwartz EN, Schwartz CA, Sebben A, Sousa MV, Fontes W, Castro MS.