General Information

    • DRAMP ID

    • DRAMP01175

    • Peptide Name

    • Ocellatin-5 (Frogs, amphibians, animals)

    • Source

    • Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AVLDILKDVGKGLLSHFMEKV

    • Sequence Length

    • 21

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.19739090]Gram-postive bacterium: Staphylococcus aureus(100% inhibition at 64μg/mL);
      • Gram-negative bacterium: Escherichia coli(100% inhibition at 32μg/mL).

    • Hemolytic Activity

      • [Ref:19739090]Show hemolytic activity

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01175 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01175.

Physicochemical Information

    • Formula

    • C106H178N26O29S

    • Absent Amino Acids

    • CNPQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 2312.8

    • PI

    • 6.8

    • Basic Residues

    • 4

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +1

    • Boman Index

    • -3.22

    • Hydrophobicity

    • 0.562

    • Aliphatic Index

    • 139.05

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP01175

DRAMP01175 chydropathy plot

Comments Information

    • Function

    • Has hemolytic and antibacterial activities.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

Literature Information

  • ·Literature 1

    • Title

    • Leptodactylus ocellatus (Amphibia): mechanism of defense in the skin and molecular phylogenetic relationships.

    • Reference

    • J Exp Zool A Ecol Genet Physiol. 2010 Jan 1;313(1):1-8.

    • Author

    • Leite JM Jr, Silva LP, Silva-Leite RR, Ferrari AS, Noronha SE, Silva HR, Bloch C Jr, Leite JR.
  • ·Literature 2

    • Title

    • Cytolytic peptides and proteases from the skin secretion of the frog Leptodactylus ocellatus).

    • Pubmed ID

    • Reference

    • Thesis (2007), University of Brasilia, Brazil

    • Author

    • Nascimento A.C.C.