General Information

    • DRAMP ID

    • DRAMP01179

    • Peptide Name

    • Ocellatin-V1 (Frogs, amphibians, animals)

    • Source

    • Leptodactylus validus Garman (Caribbean frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GVVDILKGAGKDLLAHALSKLSEKV

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01179 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01179.

Physicochemical Information

    • Formula

    • C115H201N31O34

    • Absent Amino Acids

    • CFMNPQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 2562.05

    • PI

    • 8.44

    • Basic Residues

    • 5

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • -8.02

    • Hydrophobicity

    • 0.376

    • Aliphatic Index

    • 140.4

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01179

DRAMP01179 chydropathy plot

Comments Information

    • Function

    • The very low antimicrobial potency (MIC>200 µM) against Escherichia coli and Staphylococcus aureus associated with the peptides is probably a consequence of their lack of amphipathicity and reduced cationicity compared with active members of the ocellatin family from related species.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of antimicrobial peptides from the Caribbean frog, Leptodactylus validus (Anura: Leptodactylidae).

    • Reference

    • Peptides. 2008 Aug;29(8):1287-1292.

    • Author

    • King JD, Leprince J, Vaudry H, Coquet L, Jouenne T, Conlon JM.