• DRAMP ID

    • DRAMP01180
    • Peptide Name

    • Ocellatin-V2 (Frogs, amphibians, animals)
    • Source

    • Leptodactylus validus Garman (Caribbean frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GVLDILKGAGKDLLAHALSKISEKV
    • Sequence Length

    • 25
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01180 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01180.
    • Formula

    • C116H203N31O34
    • Absent Amino Acids

    • CFMNPQRTWY
    • Common Amino Acids

    • L
    • Mass

    • 2576.07
    • PI

    • 8.44
    • Basic Residues

    • 5
    • Acidic Residues

    • 3
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +2
    • Boman Index

    • -7.14
    • Hydrophobicity

    • 0.388
    • Aliphatic Index

    • 144.4
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 5

DRAMP01180

DRAMP01180 chydropathy plot
    • Function

    • The very low antimicrobial potency (MIC>200 µM) against Escherichia coli and Staphylococcus aureus associated with the peptides is probably a consequence of their lack of amphipathicity and reduced cationicity compared with active members of the ocellatin family from related species.
  • ·Literature 1
    • Title

    • Purification and characterization of antimicrobial peptides from the Caribbean frog, Leptodactylus validus (Anura: Leptodactylidae).
    • Reference

    • Peptides. 2008 Aug;29(8):1287-1292.
    • Author

    • King JD, Leprince J, Vaudry H, Coquet L, Jouenne T, Conlon JM.