General Information
-
DRAMP ID
- DRAMP01181
-
Peptide Name
- Ocellatin-V3 (Frogs, amphibians, animals)
-
Source
- Leptodactylus validus Garman (Caribbean frog)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GVLDILTGAGKDLLAHALSKLSEKV
-
Sequence Length
- 25
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01181.
Physicochemical Information
-
Formula
- C114H198N30O35
Absent Amino Acids
- CFMNPQRWY
Common Amino Acids
- L
Mass
- 2549.01
PI
- 6.75
Basic Residues
- 4
Acidic Residues
- 3
Hydrophobic Residues
- 12
Net Charge
- +1
-
Boman Index
- -4.16
Hydrophobicity
- 0.488
Aliphatic Index
- 144.4
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 6
DRAMP01181
Comments Information
Function
- The very low antimicrobial potency (MIC>200 µM) against Escherichia coli and Staphylococcus aureus associated with the peptides is probably a consequence of their lack of amphipathicity and reduced cationicity compared with active members of the ocellatin family from related species.
Literature Information
- ·Literature 1
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Title
- Purification and characterization of antimicrobial peptides from the Caribbean frog, Leptodactylus validus (Anura: Leptodactylidae).
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Pubmed ID
- 18501993
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Reference
- Peptides. 2008 Aug;29(8):1287-1292.
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Author
- King JD, Leprince J, Vaudry H, Coquet L, Jouenne T, Conlon JM.