General Information

    • DRAMP ID

    • DRAMP01183

    • Peptide Name

    • Syphaxin (SPX; Frogs, amphibians, animals)

    • Source

    • Leptodactylus syphax (Burgundy thin-toed frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GVLDILKGAAKDLAGHVATKVINKI

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • [Swiss_Prot Entry P85279]show antibacterial activity

    • Hemolytic Activity

      • [Ref:17628627]Show hemolytic activity

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01183 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01183.

Physicochemical Information

    • Formula

    • C115H202N32O32

    • Absent Amino Acids

    • CEFMPQRSWY

    • Common Amino Acids

    • AK

    • Mass

    • 2545.06

    • PI

    • 9.53

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +3

    • Boman Index

    • -1.81

    • Hydrophobicity

    • 0.54

    • Aliphatic Index

    • 144.4

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01183

DRAMP01183 chydropathy plot

Comments Information

    • Function

    • Has hemolytic and antibacterial activity. PTM

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptide from the skin secretion of the frog Leptodactylus syphax.

    • Reference

    • Toxicon. 2007 Sep 15;50(4):572-580.

    • Author

    • Dourado F.S, Leite J.R.S.A, Silva L.P, Melo J.A.T, Bloch C. Jr, Schwartz E.F.