General Information

    • DRAMP ID

    • DRAMP01188

    • Peptide Name

    • Chensinin-1ZHa (Frogs, amphibians, animals)

    • Source

    • Rana zhenhaiensis (Chinese brown frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LALKSGGWLRLFGLKDKKH

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus ATCC 2592 (MIC=17 µM);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=35 µM), Pseudomonas aeruginosa ATCC 9027 (MIC=9 µM).
      • Yeast: Candida albicans ATCC 2002 (MIC=35 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01188 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C102H167N29O23

    • Absent Amino Acids

    • CEIMNPQTVY

    • Common Amino Acids

    • L

    • Mass

    • 2167.63

    • PI

    • 10.46

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +5

    • Boman Index

    • -19.36

    • Hydrophobicity

    • -0.321

    • Aliphatic Index

    • 107.89

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 305.56

    • Polar Residues

    • 4

DRAMP01188

DRAMP01188 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Molecular Cloning and Functional Characterization of Novel Antimicrobial Peptides from the Skin of Brown Frog, Rana zhenhaiensis.

    • Reference

    • Zoolog Sci. 2012 Sep;29(9):553-558.

    • Author

    • Xu B, Che H, Kang L, Zheng S, Mu S, Wan F.