• DRAMP ID

    • DRAMP01189
    • Peptide Name

    • Andersonin-W1 (Frogs, amphibians, animals)
    • Source

    • Odorrana andersonii (Golden crossband frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • ATNIPFKVHFRCKAAFC
    • Sequence Length

    • 17
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=23.5 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC>47 µg/ml);
      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>47 µg/ml);
      • Yeast: Candida albicans ATCC 2002 (MIC=47 µg/ml).
    • Hemolytic Activity

      • [Ref:22029824] It has no hemolytic activity against human red blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys12 and Cys17)
    • Other Modifications and Unusual Amino Acids

    • Disulfide bond between Cys12 and Cys17.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • PDB ID

    • None
    • DRAMP01189 helical wheel diagram
    • Formula

    • C90H137N25O20S2
    • Absent Amino Acids

    • DEGLMQSWY
    • Common Amino Acids

    • AF
    • Mass

    • 1953.35
    • PI

    • 9.51
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +4
    • Boman Index

    • -14
    • Hydrophobicity

    • 0.365
    • Aliphatic Index

    • 57.65
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 7.81
    • Polar Residues

    • 4

DRAMP01189

    • Function

    • Active against bacteria and fungi.
  • ·Literature 1
    • Title

    • Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
    • Reference

    • J Proteome Res. 2012 Jan 1;11(1):306-319.
    • Author

    • Yang X, Lee WH, Zhang Y.