General Information
-
DRAMP ID
- DRAMP01191
-
Peptide Name
- Andersonin-X1 (Frogs, amphibians, animals)
-
Source
- Odorrana andersonii (Golden crossband frog)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GLFSKFAGKGIVNFLIEGVE
-
Sequence Length
- 20
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
-
Target Organism
-
- [Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=30.5 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=15.3 µg/ml);
- Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=15.3 µg/ml);
- Yeast: Candida albicans ATCC 2002 (MIC=30.5 µg/ml).
-
Hemolytic Activity
-
- [Ref:22029824]Not found
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP01191_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C101H157N23O27
Absent Amino Acids
- CDHMPQRTWY
Common Amino Acids
- G
Mass
- 2125.5
PI
- 6.14
Basic Residues
- 2
Acidic Residues
- 2
Hydrophobic Residues
- 10
Net Charge
- 0
-
Boman Index
- 7.51
Hydrophobicity
- 0.725
Aliphatic Index
- 112
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 6
DRAMP01191
Comments Information
Function
- Active against bacteria and fungi.
Literature Information
- ·Literature 1
-
Title
- Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
-
Pubmed ID
- 22029824
-
Reference
- J Proteome Res. 2012 Jan 1;11(1):306-319.
-
Author
- Yang X, Lee WH, Zhang Y.