General Information

    • DRAMP ID

    • DRAMP01200

    • Peptide Name

    • Hejiangin-F1 (frog, amphibians, animals)

    • Source

    • Odorrana hejiangensis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • IPWKLPATFRPVERPFSKPFCRKD

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC>100 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=100 µg/ml);
      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=100 µg/ml);
      • Yeast: Candida albicans ATCC 2002 (MIC=100 µg/ml).

    • Hemolytic Activity

      • [Ref:22029824]Non-hemolytic activity against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01200 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01200.

Physicochemical Information

    • Formula

    • C138H211N37O31S

    • Absent Amino Acids

    • GHMNQY

    • Common Amino Acids

    • P

    • Mass

    • 2916.48

    • PI

    • 10.3

    • Basic Residues

    • 6

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +4

    • Boman Index

    • -54.67

    • Hydrophobicity

    • -0.725

    • Aliphatic Index

    • 48.75

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 239.13

    • Polar Residues

    • 3

DRAMP01200

DRAMP01200 chydropathy plot

Comments Information

    • Function

    • Weakly active against bacteria and fungi and has no hemolytic activity under the test conditions.

Literature Information

  • ·Literature 1

    • Title

    • Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.

    • Reference

    • J Proteome Res. 2012 Jan 1;11(1):306-319.

    • Author

    • Yang X, Lee WH, Zhang Y.