General Information
-
DRAMP ID
- DRAMP01201
-
Peptide Name
- Schmackerin-C1 (Frogs, amphibians, animals)
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Source
- Odorrana schmackeri
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Family
- Not found
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Gene
- Not found
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Sequence
- AAPRGGKGFFCKLFKDC
-
Sequence Length
- 17
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=100 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=50 µg/ml);
- Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=50 µg/ml).
- Yeast: Candida albicans ATCC 2002 (MIC=100 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
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N-terminal Modification
- Free
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C-terminal Modification
- Cyclization (Cys11 and Cys17)
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Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys11 and Cys17.
-
Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01201.
Physicochemical Information
-
Formula
- C84H129N23O20S2
Absent Amino Acids
- EHIMNQSTVWY
Common Amino Acids
- FGK
Mass
- 1845.21
PI
- 9.39
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 6
Net Charge
- +3
-
Boman Index
- -17.43
Hydrophobicity
- -0.1
Aliphatic Index
- 34.71
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 7.81
Polar Residues
- 5
DRAMP01201
Comments Information
Function
- Schmackerin-C1 showes killing effects against the tested strains.
Literature Information
- ·Literature 1
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Title
- Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
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Pubmed ID
- 22029824
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Reference
- J Proteome Res. 2012 Jan 1;11(1):306-319.
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Author
- Yang X, Lee WH, Zhang Y.